Author

Tom C. M. Seegar

University of CincinnatiORCID 0000-0003-1258-6371Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Bryce Guion· 1 shared Carl BlobeliD· 1 shared Conner E. Slone· 1 shared Hala F. Alnajjar· 1 shared Igal IferganiD· 1 shared Joseph J. MaciagiD· 1 shared Maria F. Rich· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Bryce Guion

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1 paper

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedJun 13, 2025

Structural Insights into the Activation and Inhibition of the ADAM17-iRhom2 Complex

Joseph J. Maciag, Conner E. Slone, Hala F. Alnajjar…·Tom C. M. Seegar

The paper presents the cryo-EM structure of the ADAM17-iRhom2 complex, elucidates its inhibitory mechanisms, and validates findings with cellular assays.

8 citations

cryo-EMexperimental assay

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