Igal Ifergan

This study identifies Ninjurin-1 as a key mediator of myeloid cell adhesion and inflammation in RR-EAE, showing its therapeutic potential in relapsing-remitting MS.

This study identifies Tregs as a source of canonical WNT ligands that suppress effector CD4+ T cell responses through WNT signaling.

This study identifies an interoceptive circuit between the subfornical organ and infralimbic cortex that mediates airway inflammation's impact on fear extinction in mice.

The paper presents the cryo-EM structure of the ADAM17-iRhom2 complex, elucidates its inhibitory mechanisms, and validates findings with cellular assays.

This study shows that activating the Wnt signaling pathway in myeloid cells reduces neuroinflammation and disease severity in experimental autoimmune encephalomyelitis, suggesting a potential therapy for multiple sclerosis.

This study identifies microglia as the primary source of TGF-β1 ligand in the adult mouse brain, showing its role in maintaining microglial homeostasis and cognitive function through an autocrine mechanism.