David I. Hughes

The paper discovers a new synaptic structure called the Honeycomb Synapse in the spinal cord, showing its vulnerability in ALS models.

This study shows that NPY-expressing inhibitory interneurons in the spinal dorsal horn reduce pain and itch behaviors, suggesting they are potential targets for treating pathological pain and itch.

The paper identifies that excitatory and inhibitory parvalbumin interneurons in the spinal dorsal horn form distinct circuits and that excitatory interneurons contribute to mechanical hypersensitivity under pathological conditions.

This study identifies calretinin-positive neurons in the spinal cord dorsal horn as part of an excitatory network that amplifies pain signals and is a potential target for analgesic therapies.