Brett Anthony Graham

This study shows that optogenetic activation of hypothalamic CRH neurons increases stress-related behaviors and reduces sucrose motivation, suggesting a role for these neurons in motivational drive.

This study introduces an optical method to measure nociceptive thresholds in mice using photostimulation of TRPV1-expressing nociceptors, showing it can detect analgesic effects like morphine.

The paper identifies that excitatory and inhibitory parvalbumin interneurons in the spinal dorsal horn form distinct circuits and that excitatory interneurons contribute to mechanical hypersensitivity under pathological conditions.

This study investigates how ventral striatopallidal neurons modulate orexin/hypocretin neuron activity in response to food and metabolic states, revealing their role in reward-seeking behavior.

This study identifies calretinin-positive neurons in the spinal cord dorsal horn as part of an excitatory network that amplifies pain signals and is a potential target for analgesic therapies.

This study shows that activating group III mGluRs in the lateral hypothalamus reduces orexin cell activity and suppresses cocaine-seeking behavior during abstinence.