Li Guan

This paper evaluates statistical methods for assessing differences between surrogate and patient samples in NGS-based assays using simulated data and recommends specific approaches for different scenarios.

The paper identifies monoamine receptors in placozoans and shows they respond to monoamines, suggesting monoaminergic signalling originated before bilaterians.

The paper identifies additional eQTL signals in adipose tissue and shows they contribute to cardiometabolic traits through gene dosage effects.

APEX is a toolkit for molecular QTL mapping and meta-analysis that improves scalability and accuracy for large datasets and summary statistics.

The paper identifies genetic-environment interactions in skeletal muscle gene expression using allele-specific expression and clinical traits as environmental proxies.