Luis Alfonso Yáñez-Guerra

This study shows that cholinergic and monoaminergic signaling originated before Bilateria, using a combination of metabolomics, phylogenetics, and single-cell analysis.

This paper identifies and characterizes an allatostatin C GPCR system in Octopus vulgaris, revealing two receptors with distinct potency in response to the same peptide.

This study identifies and functionally validates TRPV channels in Octopus vulgaris as polymodal nociceptors using in silico analysis and heterologous expression in model organisms.

The paper investigates the evolution and functional properties of Epsilon receptors in placozoa, revealing molecular determinants for ligand specificity and polyamine regulation.

The paper identifies monoamine receptors in placozoans and shows they respond to monoamines, suggesting monoaminergic signalling originated before bilaterians.

This study identifies the ancient eukaryotic origins and conservation of NALCN/Cch1 channelosome subunits across animals, fungi, and apusomonads.

NP-HMMer identifies neuropeptides across diverse species by using HMMs for 46 families, discovering novel peptides in Priapulida and Rotifera.

The paper identifies a NO-mediated retrograde signaling pathway in ciliary photoreceptor cells that gates a UV avoidance circuit in Platynereis dumerilii larvae.

The paper identifies 31 Nematostella vectensis GPCRs activated by 14 neuropeptides, showing cnidarian and bilaterian peptidergic systems expanded independently.

The paper identifies two neuropeptide precursors with broad evolutionary conservation, suggesting neuropeptide signaling originated before neurons.

The paper identifies an sNPF-type neuropeptide ligand in a deuterostome, showing its evolutionary origin in Urbilateria and loss in echinoderms.

The paper identifies novel neuropeptide precursors in brittle stars and analyzes their evolutionary changes over 270 million years.