Author

Corrado Santocanale

Ollscoil na Gaillimhe – University of GalwayORCID 0000-0003-1337-5656Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Colm J. RyaniD· 2 shared Michael D. RaineyiD· 2 shared Stefanus BernardiD· 2 shared Aikaterini Pravi· 1 shared Dominik BoosiD· 1 shared Liadhan FarrelliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersBioinformatics

Colm J. RyanORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintAug 20, 2026

A survey of multi-targeting and off-targeting sgRNAs across five genome-wide CRISPR-Cas9 knockout sgRNA libraries with GuideRefine

Stefanus Bernard, Michael D. Rainey, Corrado Santocanale, Colm J. Ryan

The paper develops GuideRefine to identify and remove multi-targeting and off-targeting sgRNAs from CRISPR-KO libraries, improving the accuracy of gene hit lists.

DOI 10.64898/2026.08.20.746015

humanCRISPR screen

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BiochemistrybioRxivPreprintDec 12, 2025

CDC7 and CDK8 kinases cooperate to support DNA replication origin firing in human cells

Michael D. Rainey, Stefanus Bernard, Aikaterini Pravi…·Corrado Santocanale

The paper identifies CDK8 as a third kinase involved in DNA replication origin activation by showing its cooperation with CDC7 and its role in phosphorylating MCM4.

DOI 10.64898/2025.12.09.692982

humanDNA methylation

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