Dominik Boos

The paper identifies CDK8 as a third kinase involved in DNA replication origin activation by showing its cooperation with CDC7 and its role in phosphorylating MCM4.

The paper shows that MTBP allosterically activates Cdk8-CycC kinase activity through distinct mechanisms from Med12, enabling substrate-specific phosphorylation and impacting cancer biology.

This study shows TopBP1 interacts with GINS via two distinct sites to support replication origin firing and predicts coordination of molecular processes in origin activation.

The paper investigates mutation landscape heterogeneity across individuals and cell types, identifying replication timing biases and mutation load as key factors.

The paper refines the domain architecture model of Treslin/TICRR by identifying new structural features and their functional roles in replication origin firing.