This study shows that LRP4 functions presynaptically at Drosophila neuromuscular synapses, organizing development, maturation, and cytoskeletal structure through SRPK79D.

DOI 10.1101/2023.11.03.564481

Drosophilaexperimental assay

𝕏 PostBluesky

NeuroscienceJournal of NeurosciencePeer-reviewedNov 29, 2022

Different olfactory neuron classes use distinct temporal and molecular programs to complete synaptic development

Michael A. Aimino, Alison T. DePew, Lucas Restrepo, Timothy J. Mosca

15 citations

Drosophilaexperimental assay

𝕏 PostBluesky

NeuroscienceDevelopmental CellPeer-reviewedJun 1, 2022

γ-secretase promotes postsynaptic maturation through the cleavage of a Wnt receptor

Lucas J. Restrepo, Alison T. DePew, Elizabeth R. Moese…·Timothy J. Mosca

This study shows γ-secretase promotes postsynaptic maturation by cleaving the Wnt receptor Fz2 in Drosophila, linking synaptic development to neurodegenerative disease mechanisms.

33 citations

Drosophilaexperimental assay

𝕏 PostBluesky

NeuroscienceFrontiers in NeurosciencePeer-reviewedJan 29, 2019

The Tenets of Teneurin: Conserved Mechanisms Regulate Diverse Developmental Processes in the Drosophila Nervous System

Alison T. DePew, Michael A. Aimino, Timothy J. Mosca

This review discusses how Teneurin proteins use conserved mechanisms to regulate diverse developmental processes in the Drosophila nervous system, including axon guidance, partner matching, and synapse formation.

19 citations

Drosophila

𝕏 PostBluesky