Timothy J. Mosca

The paper identifies FBXW11 as a negative regulator of radial glial expansion and neuronal maturation in human cerebral organoids through CRISPR screening and functional validation.

This study shows that LRP4 functions presynaptically at Drosophila neuromuscular synapses, organizing development, maturation, and cytoskeletal structure through SRPK79D.

The paper introduces SynLight, a dicistronic construct that simultaneously labels presynaptic active zones and neuronal membranes in Drosophila, demonstrating its effectiveness in visualizing and quantifying synapses.

The paper introduces a conditional marker, dlg1[4K], to label endogenous excitatory postsynapses in Drosophila and reveals distinct subsynaptic organization rules across neuron classes.

The paper shows that sequential axon arrival and physical occupancy determine the integration of visual projection neurons onto the dendrites of the giant fiber in Drosophila.

This study shows γ-secretase promotes postsynaptic maturation by cleaving the Wnt receptor Fz2 in Drosophila, linking synaptic development to neurodegenerative disease mechanisms.

The paper identifies Zn72D as a regulator of ADAR-mediated RNA editing in Drosophila neurons and shows its conservation in mammals.

This review discusses how Teneurin proteins use conserved mechanisms to regulate diverse developmental processes in the Drosophila nervous system, including axon guidance, partner matching, and synapse formation.

This study shows that presynaptic LRP4 promotes synapse number and function in excitatory CNS neurons in Drosophila by acting through SRPK79D.