Claire L. Smillie

The paper profiles the morphological effects of 2,565 human and 1,900 mouse miRNAs on 24 million cells across five cell lines, finding that 9% and 15% of miRNA mimics significantly alter cell morphology.

This study identifies rs3087967 as the causal variant at 11q23.1 that increases colorectal cancer risk by dysregulating POU2AF2, a key activator of tuft cell transcription.