BiochemistrybioRxivPreprint
Bivalent Inhibitor Development for a Dynamic Epigenetic Tandem Reader Protein Using a Combinatorial Histone Code
Joseph E. McPherson, Molly Sneddon, Richard Kofi Begyinah…·William C. K. Pomerantz
This study identifies H3K4me3K14ac as the specific histone modification recognized by BPTF's PHD BRD cassette, designs a bivalent inhibitor MJ-1, and provides structural insights for therapeutic development.
DOI 10.64898/2026.10.09.758058