Bivalent Inhibitor Development for a Dynamic Epigenetic Tandem Reader Protein Using a Combinatorial Histone Code
Joseph E. McPherson, Molly Sneddon, Richard Kofi Begyinah, Kesavan Babu, Kerstin E. Peterson, Ryan F. Friess, Thomas G. Smith, Natalia Y. Tretyakova, Marcus M. Fischer, William C. K. Pomerantz
This study identifies H3K4me3K14ac as the specific histone modification recognized by BPTF's PHD BRD cassette, designs a bivalent inhibitor MJ-1, and provides structural insights for therapeutic development.
bioRxiv · Oct 16, 2026 · PreprintBiochemistry