Kexin Dong

H2M is a computational pipeline that models human genetic variants in mice by predicting equivalent mutations and creating a database of mutation pairs for functional studies.

The paper uses in vivo base editing to systematically analyze the functional impact of genetic variants in cancer models, revealing context-dependent effects and limitations of CRISPR-Cas9.

This study evaluates the functional impact of genetic variants using a high-throughput prime editing sensor strategy, identifying both known and novel TP53 variants with diverse effects on p53 function.