Author
Memorial Sloan Kettering Cancer CenterORCID 0000-0001-8970-5135Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Shandon M Amos, Chi-Chao Chen, Yichen Xiang…·Yadira M. Soto‐Feliciano
This study identifies TRIM28 as a critical regulator in acute leukemia, showing its depletion promotes neutrophil differentiation and reduces leukemic potential, with a small-molecule inhibitor developed to target it.
Jonuelle Acosta, Grace A. Johnson, Samuel I. Gould…·Francisco J. Sánchez Rivera
The paper uses in vivo base editing to systematically analyze the functional impact of genetic variants in cancer models, revealing context-dependent effects and limitations of CRISPR-Cas9.
Samuel I. Gould, Alexandra N. Wuest, Kexin Dong…·Francisco J. Sánchez Rivera
This study evaluates the functional impact of genetic variants using a high-throughput prime editing sensor strategy, identifying both known and novel TP53 variants with diverse effects on p53 function.
Ozgur Oksuz, Varun K. Narendra, Chul‐Hwan Lee…·Danny Reinberg
The paper demonstrates a two-step mechanism of PRC2-mediated repressive domain formation through nucleation sites and long-range spreading of H3K27me2/3.