Author

Grace A. Johnson

Koch Institute for Integrative Cancer Research At MIT

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Francisco J. Sánchez RiveraiD· 4 shared Alexandra N. WuestiD· 3 shared Samuel I. GouldiD· 3 shared Varun K. NarendraiD· 3 shared Angela N. KoehleriD· 2 shared Jonuelle AcostaiD· 2 shared Kexin DongiD· 2 shared Manuel E. Contreras· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCancer Biology

Francisco J. Sánchez RiveraORCID

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4 papers

Recent·Most cited

Epigenetic Reactivation of Lineage Differentiation to Target Leukemia

Shandon M Amos, Chi-Chao Chen, Yichen Xiang, Keisuke Motoyama, Tania J González-Robles, Varun K. Narendra, Grace A. Johnson, Han‐Teo Lee, Yu-Jui Ho, Ipek Celikoyar, Ziyang Ye, Shenghao Guo, Claire Glickman, Natalie A. O’Hearn, Oindrila Sarkar, , Yadira M. Soto‐Feliciano

This study identifies TRIM28 as a critical regulator in acute leukemia, showing its depletion promotes neutrophil differentiation and reduces leukemic potential, with a small-molecule inhibitor developed to target it.

bioRxiv · Jul 10, 2026 · PreprintCancer Biology

A functional map of CDK-drug interactions at single amino acid resolution

Samuel I. Gould, Jonuelle Acosta, Luca Boscolo Bielo, Alinur Jaboldinov, Grace A. Johnson, Manuel E. Contreras, Alexandra N. Wuest, Emmanuel Brémont, Mohammed A. Toure, Yichen Xiang, Zuzanna Kozicka, Michael T. Hemann, Angela N. Koehler, Sarat Chandarlapaty, Francisco J. Sánchez Rivera

The paper maps CDK-drug interactions at single amino acid resolution using genome editing and computational analysis, identifying critical residues and resistance mechanisms.

bioRxiv · Nov 2, 2025 · PreprintCancer Biology

Multiplexed in vivo base editing identifies functional gene-variant-context interactions

Jonuelle Acosta, Grace A. Johnson, Samuel I. Gould, Kexin Dong, Yovel Lendner, Diego Detrés, Ondine Atwa, Jari Bulkens, Samuel Gruber, Manuel E. Contreras, Alexandra N. Wuest, Varun K. Narendra, Michael T. Hemann, Francisco J. Sánchez Rivera

The paper uses in vivo base editing to systematically analyze the functional impact of genetic variants in cancer models, revealing context-dependent effects and limitations of CRISPR-Cas9.

bioRxiv · Feb 23, 2025 · PreprintCancer Biology

High throughput evaluation of genetic variants with prime editing sensor libraries

Samuel I. Gould, Alexandra N. Wuest, Kexin Dong, Grace A. Johnson, Alvin Hsu, Varun K. Narendra, Ondine Atwa, Stuart S. Levine, David R. Liu, Francisco J. Sánchez Rivera

This study evaluates the functional impact of genetic variants using a high-throughput prime editing sensor strategy, identifying both known and novel TP53 variants with diverse effects on p53 function.

Nature Biotechnology · Mar 12, 2024Peer-reviewedGenetics