Maria Ryaboshapkina

The paper identifies IAPP as a marker for mature stem cell-derived β cells that maintain stable insulin production in vitro and in vivo, and finds that aconitine enhances IAPP expression.

The paper validates EndoC-βH1 as a translational human β cell model using omics and characterizes its secretome, finding it secretes 671 proteins in baseline and 3,278 under stress, with exosome secretion as a major mode.

The paper examines tissue-specific genes as potential drug targets, finding they are overrepresented in marketed drugs but underutilized in clinical trials, with implications for drug efficacy and evolutionary constraints.