Alejandro Jiménez-Sánchez

The paper analyzes transcriptomic changes in metastatic pancreatic cancer using a patient's autopsy data to identify site-specific gene programs and clonal phylogeny.

The paper analyzes whole-genome sequencing data from melanoma metastases to show that branched evolution is common and that subclonal heterogeneity is prevalent in metastatic melanoma.

This study benchmarks six cell estimation tools and introduces ConsensusTME, which performs consistently well across multiple cancer-related benchmarks.

The paper quantifies neoantigen depletion in cancer genomes and finds negligible depletion signals, suggesting weak or absent immunogenic negative selection.