Lei Sun

MuSIC predicts cross-species RBP-RNA interactions using evolutionary conservation and label smoothing, outperforming existing methods and quantifying variant effects on binding.

The paper identifies dysregulated RNA G-quadruplex binding proteins (RG4BPs) in Alzheimer's Disease, linking their altered expression to glial cell dysfunction and stress state shifts.

The paper identifies a temporal genetic program in early neurogenesis, revealing molecular heterogeneity and gene expression dynamics in preplate and Cajal-Retzius neurons.

This study identifies RNA structural elements in ZIKV strains that influence infectivity through comparative in vivo analysis.