Cancer BiologybioRxivPreprint
Actionable biological programs to enhance EGFR-targeted therapy response unveiled by single-cell lineage tracing in clinically relevant lung cancer models
Beatrice Gini, Whitney Tamaki, Johnny X. Yu…·Trever Grant Bivona
This study uses single-cell lineage tracing and RNAseq to identify pre-existing resistant tumor subclones in lung cancer models and their transcriptional programs, revealing mechanisms of therapy resistance.