Author

John B. MacMillan

University of California, Santa CruzORCID 0000-0003-1430-1077Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:experimental assay· 1 Assay:imaging· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Akshar LohithiD· 2 shared Derfel TercianoiD· 2 shared R. Scott LokeyiD· 2 shared Adam MurrayiD· 1 shared Aswad KhadilkariD· 1 shared Beverley M. RabbittsiD· 1 shared Matylda ZietekiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

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2 shared papersBioinformatics

Akshar LohithORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintSep 15, 2025

MOAST: Mechanism of Action Similarity Tool

Akshar Lohith, Derfel Terciano, Adam Murray…·R. Scott Lokey

MOAST provides a rapid, accessible tool for predicting mechanism of action of compounds using KDE and CatBoost, achieving better accuracy than existing methods.

DOI 10.1101/2025.09.15.676411

humanproteomics

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Systems BiologybioRxivPreprintMay 23, 2025

Cell Painting in activated cells illuminates phenotypic dark space and uncovers novel drug mechanisms of action.

Matylda Zietek, Akshar Lohith, Derfel Terciano…·R. Scott Lokey

The paper uses Cell Painting to identify phenotypic effects of compounds in activated cells, revealing novel drug mechanisms and expanding phenotypic understanding.

1 citation

humanimaging

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