Derfel Terciano

MOAST provides a rapid, accessible tool for predicting mechanism of action of compounds using KDE and CatBoost, achieving better accuracy than existing methods.

This study identifies PAPI (encoded by pcnB) as essential for maintaining virulence and AMR plasmid copy number, stability, and bacterial virulence in Yersinia and Shigella.

The paper uses Cell Painting to identify phenotypic effects of compounds in activated cells, revealing novel drug mechanisms and expanding phenotypic understanding.