R. Scott Lokey

This paper develops N-methylated and stapled peptide ligands for GABARAP with low nanomolar affinity and subfamily selectivity.

MOAST provides a rapid, accessible tool for predicting mechanism of action of compounds using KDE and CatBoost, achieving better accuracy than existing methods.

The paper uses Cell Painting to identify phenotypic effects of compounds in activated cells, revealing novel drug mechanisms and expanding phenotypic understanding.