Author

Gabriel Osborn

King's College LondonORCID 0000-0003-1439-1973Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Francesca CaponiD· 1 shared Jillian Yong Xin SiehiD· 1 shared Sophia N. KaragiannisiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperImmunology

Francesca CaponORCID

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1 paper

Recent·Most cited

ImmunologyCytokinePeer-reviewedDec 15, 2025

IL-36γ signalling promotes a proinflammatory macrophage state that is associated with reduced lipid uptake

Jillian Yong Xin Sieh, Gabriel Osborn, Sophia N. Karagiannis, Francesca Capon

This study shows that IL-36γ signaling reduces the anti-inflammatory M2a macrophage state by decreasing CD163 and lipid uptake receptors, while increasing M1 markers and cytokines.

2 citations

humanbulk RNA-seq

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