Sophia N. Karagiannis

Jagged-1+ Tregs Mediate Lymphatic Remodeling in Tumour-Draining Lymph Nodes

This study shows that Jag1-expressing regulatory T cells (Tregs) in tumor-draining lymph nodes (tdLNs) are essential for lymphatic remodeling and niche formation during melanoma progression.

Extrafollicular plasma cells disable dendritic cell-T-cell priming in tumor-draining lymph nodes

The paper identifies extrafollicular plasma cells as an antibody-independent checkpoint that inhibits dendritic cell-T-cell priming in tumor-draining lymph nodes, leading to poor prognosis and immune-checkpoint resistance.

IL-36γ signalling promotes a proinflammatory macrophage state that is associated with reduced lipid uptake

This study shows that IL-36γ signaling reduces the anti-inflammatory M2a macrophage state by decreasing CD163 and lipid uptake receptors, while increasing M1 markers and cytokines.

Tuning antibody stability and function by rational designs of framework mutations

This study designs framework mutations in antibodies to improve stability and function using a computational-experimental approach, showing that FW modifications can affect immunological functions beyond binding affinity.