Guillaume Mabilleau

GL-0001 improves bone fragility in a mouse model of osteogenesis imperfecta by enhancing bone material properties and growth, unlike bisphosphonates which primarily affect bone mass.

This paper introduces Bone Material Properties Distributions (BMPDs) to characterize biochemical heterogeneity in human bone matrix using quantitative Raman analysis, showing robustness and reproducibility across tissue processing methods.

This study identifies mitochondrial alterations in osteoarthritic chondrocytes and shows that bezafibrate improves OxPhos function in a subset of patients.

This study shows that exendin-4 improves bone strength in ovariectomized mice through a central mechanism, not directly on bone cells.

This study examines how vertical sleeve gastrectomy before pregnancy affects bone mass, microarchitecture, and material properties in female rats fed a high-fat high-sugar diet.

This study correlates Raman mineral-to-matrix ratios with weight percentage mineral-to-matrix ratios from qBEI in human bone tissue, finding v1PO4/CH2 has the strongest correlation.