Author

Claire S. Vinatier

InsermORCID 0000-0002-6063-9901Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Jérôme GuicheuxiD· 4 shared Lucie DanetiD· 3 shared Romain GuihoiD· 3 shared A. DefoisiD· 2 shared Denis WaastiD· 2 shared Frédéric BlanchardiD· 2 shared Marie‐Astrid BoutetiD· 2 shared Nicolas GaigeardiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersImmunology

Jérôme GuicheuxORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular and spatial profiling identifies immune endotypes for the stratification of OA patients

Nicolas Gaigeard, Anaïs Cardon, Romain Guiho, Cankut Çubuk, Astrid Ouattara, Celia Lamothe, Jordan Brouard, Julien De Lima, Manzoor Ahmed, Mathilde Le Mercier, A. Defois, Lucie Danet, Jimmy Perrot, Nazim Benzerdjeb, Claire S. Vinatier, , Marie‐Astrid Boutet

The paper identifies immune endotypes in OA synovial tissue using integrated molecular and spatial profiling to guide precision medicine.

bioRxiv · Jan 12, 2026 · PreprintImmunology

Transcriptomic and functional comparison of cells isolated from healthy and degenerated ovine intervertebral discs

Paul Humbert, Lucie Danet, Emmaëlle Carrot, Floriane Etienne, Boris Halgand, Frédéric Blanchard, Claire S. Vinatier, Jérôme Guicheux, Marion Fusellier, Catherine Le Visage, Romain Guiho

This paper compares transcriptomic and functional differences between healthy and degenerated ovine intervertebral disc cells, finding age-related inflammatory and senescence signatures and shared transcriptional modules with human degenerated discs.

Journal of Cellular and Molecular Medicine · Jan 1, 2026Peer-reviewedCell Biology

Multimodal analysis of osteoarthritic chondrocytes reveals mitochondrial alterations and patient-specific OxPhos response to bezafibrate

Lucie Danet, Romain Guiho, Sally Hussein, A. Defois, Nicolas Gaigeard, Joëlle Véziers, Guillaume Mabilleau, Antoine Hamel, Denis Waast, Jérôme Guicheux, Marie‐Astrid Boutet, Claire S. Vinatier

This study identifies mitochondrial alterations in osteoarthritic chondrocytes and shows that bezafibrate improves OxPhos function in a subset of patients.

bioRxiv · Oct 28, 2025 · PreprintPathology

EZH2 coordinates inflammatory and pain-associated pathways across joint compartments in osteoarthritis

Sybille Brochard, Alison Vanlaeys, Mahdia Taieb, Isabelle Richard, Juliette Aury‐Landas, Benoı̂t Bernay, Julien Pontin, Célia Seillier, Nina Bon, Baptiste Picart, Claire Pecqueur, Olivier Toutirais, Claire S. Vinatier, Jérôme Guicheux, Eric Maubert, , Catherine Baugé

This study shows EZH2 inhibition reduces cartilage damage, synovial inflammation, and pain in OA by modulating inflammatory, neuroimmune, and osteoimmune pathways.

bioRxiv · Jan 19, 2025 · PreprintPhysiology