Author

Paula M. Alves

Instituto de Biologia Experimental e TecnológicaORCID 0000-0003-1445-3556Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Catarina BritoiD· 3 shared Catarina Monteiro GomesiD· 2 shared Ana Sofia CoroadinhaiD· 1 shared Catarina FreitasiD· 1 shared Daniel F. SimãoiD· 1 shared Diana Duarte LoboiD· 1 shared Francisca Arez· 1 shared François du Plessis· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBioengineering

Catarina BritoORCID

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3 papers

Recent·Most cited

ImmunologyScientific ReportsPeer-reviewedDec 6, 2025

3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV

Isabella Ramella Gal, Francisca Arez, Inês P. Correia…·Catarina Brito

This study develops a 3D co-culture model of human hepatocytes and Kupffer-like cells to investigate innate immune responses to rAAV vectors.

4 citations

humanexperimental assay

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BioengineeringBiotechnology and BioengineeringPeer-reviewedNov 12, 2025

Engineering a perfusion bioreactor system for hiPSC-derived progenitor co-culture capturing microglial features in CNS development

Catarina Monteiro Gomes, Inês de Sá, Margarida Delgado…·Catarina Brito

This study develops a perfusion bioreactor system to co-culture hiPSC-derived erythromyeloid progenitors with neurospheres, mimicking microglial features in CNS development.

1 citation

humanbulk RNA-seq

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BioengineeringbioRxivPreprintJul 7, 2025

Innate immunocompetent iNSpheroids: A hiPSC-derived 3D model to study the central nervous system captures an early CNS response to rAAV

Catarina Monteiro Gomes, Gabriela Priscila de Lima Silva, Mafalda M Aleixo…·Catarina Brito

The paper develops a 3D human CNS model from hiPSCs to study immune responses to rAAV gene therapy, finding that iMGL-iNSpheroids show mild, transient inflammation to rAAV9.

DOI 10.1101/2025.07.07.662807

humanspatial transcriptomics

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