Author

Daniel F. Simão

Instituto de Biologia Experimental e TecnológicaORCID 0000-0002-7532-8081Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Catarina BritoiD· 1 shared Catarina Monteiro GomesiD· 1 shared Diana Duarte LoboiD· 1 shared Gabriela Priscila de Lima SilvaiD· 1 shared Lekh N. DahaliD· 1 shared Luís Pereira de AlmeidaiD· 1 shared Mafalda M Aleixo· 1 shared Mark Trautwein· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioengineering

Catarina BritoORCID

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1 paper

Recent·Most cited

BioengineeringbioRxivPreprintJul 7, 2025

Innate immunocompetent iNSpheroids: A hiPSC-derived 3D model to study the central nervous system captures an early CNS response to rAAV

Catarina Monteiro Gomes, Gabriela Priscila de Lima Silva, Mafalda M Aleixo…·Catarina Brito

The paper develops a 3D human CNS model from hiPSCs to study immune responses to rAAV gene therapy, finding that iMGL-iNSpheroids show mild, transient inflammation to rAAV9.

DOI 10.1101/2025.07.07.662807

humanspatial transcriptomics

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