E. Kelly Buchanan

This study examines age-related changes in neural and behavioural variability during a decision-making task in mice, finding increased neural variability and reduced variability quenching in specific brain regions.

Mice infer stimulus-side priors from recent choices; prior signals are decodable pre-stimulus in 24.0% to 30.2% of 242 brain regions, including early visual and motor areas.

This paper introduces CANDY, a framework that aligns neural and behavioral data across sessions and subjects, enabling cross-session behavior decoding and identifying shared neural dynamics.

This paper introduces a cloud-based platform that provides automated, reproducible, and accessible data analysis tools for neuroscience, improving efficiency and reducing infrastructure barriers.

This paper introduces a video analysis tool that combines supervised pose estimation with unsupervised dimensionality reduction to extract interpretable behavioral features from animal videos, improving downstream analyses.

The paper develops all-optical electrophysiology tools to record subthreshold dynamics and excitability in mouse hippocampus during behavior, revealing brain-state dependent changes in neuronal activity.

~2-4x SNR gains and 20-300x compression on calcium and voltage imaging, from a patch-wise penalized matrix decomposition that splits signal from temporally uncorrelated noise without hyperparameter tuning.