Anup Khanal

Age-related changes in behavioural and neural variability in a decision-making task

This study examines age-related changes in neural and behavioural variability during a decision-making task in mice, finding increased neural variability and reduced variability quenching in specific brain regions.

Brain-wide representations of prior information in mouse decision-making

Mice infer stimulus-side priors from recent choices; prior signals are decodable pre-stimulus in 24.0% to 30.2% of 242 brain regions, including early visual and motor areas.

A Brain-Wide Map of Neural Activity during Complex Behaviour

The paper presents a brain-wide neural activity map from 621,733 neurons across 139 mice performing a decision-making task, showing how neural activity encodes task variables across brain regions.

A common computational and neural anomaly across mouse models of autism

The paper shows that mice with ASD-related mutations exhibit similar computational and neural anomalies in prior updating during decision-making.

Reproducibility of in-vivo electrophysiological measurements in mice

This study evaluates the reproducibility of electrophysiological measurements across ten labs using standardized protocols and finds that variability in electrode targeting and statistical methods affects reproducibility.

Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling, and cloud-native open-source tools

Interactive data exploration websites for large-scale electrophysiology

The paper introduces two public websites for exploring large-scale electrophysiology data from the International Brain Laboratory, enabling cross-platform access to behavioral trials and neuronal data.

Large scale, simultaneous, chronic neural recordings from multiple brain areas

The paper introduces a method for chronic, simultaneous neural recordings from multiple brain areas in mice, enabling long-term and flexible monitoring of neural activity during behavior.

Data architecture for a large-scale neuroscience collaboration

The paper describes a modular data architecture for a neuroscience collaboration, enabling data contribution, access, and analysis across multiple labs.

Standardized and reproducible measurement of decision-making in mice

This paper develops a standardized task for measuring decision-making in mice, showing reproducible results across multiple laboratories and providing a public dataset and tools.

Lapses in perceptual judgments reflect exploration

This study shows that lapses in perceptual decisions in rats reflect a strategic trade-off between exploration and exploitation, and are informative about decision-related computations in neural structures.