Hannah A. Pliner

The paper identifies de-novo SPTLC1 mutations in juvenile ALS patients and suggests serine supplementation may alleviate symptoms.

Garnett enables rapid cell type annotation in scRNA-seq and scATAC-seq data using a hierarchical markup language of cell type-specific genes.

The paper presents a single-cell chromatin accessibility map of the mouse hippocampus using sci-ATAC-seq, identifies cell-type-specific regulatory networks, and provides a resource for future studies.

The paper profiles chromatin accessibility in Drosophila embryos to uncover cis-regulatory programs and cell fate determinants during development.

Monocle 2 learns branched single-cell trajectories without supervision via reversed graph embedding, revealing a non-fusing myoblast outcome and knockout myeloid cells diverted onto opposite fate branches.

The paper introduces Cicero, a statistical method to link regulatory elements to target genes using single-cell chromatin accessibility data, and applies it to study myogenesis.