Cis acting variation is common, can propagates across multiple regulatory layers, but is often buffered in developmental programs
Swann Floc’hlay, Emily S. W. Wong, Bingqing Zhao, Rebecca R. Viales, Morgane Thomas‐Chollier, Denis Thieffry, David A. Garfield, Eileen E. M. Furlong
The paper quantifies how cis-acting genetic variation affects chromatin accessibility, histone modifications, and gene expression in Drosophila embryos, finding that much of this variation does not propagate to gene expression.
Genome Research · Feb 1, 2021Peer-reviewedGenomics