Thomas N. Seyfried

This study compares bioenergetic profiles of non-tumor and tumor cells to distinguish Crabtree and Warburg effects in mouse cells.

Intravenous AAV gene therapy extends lifespan and improves clinical outcomes in feline Sandhoff Disease by reducing GM2 ganglioside accumulation and neuroinflammation.

This study examines the effect of glutamine supplementation on glioma growth in orthotopic and subcutaneous models, finding no effect on orthotopic growth but significant increases in subcutaneous tumor volume.

This study shows lactate cannot replace glucose to maintain viability in mouse and human glioma cells, but supports lactate utilization in non-neoplastic macrophages.

This study shows that malignant glioma cells rely on amino acid and glucose fermentation for ATP production, not oxidative phosphorylation, and that glutamine is essential for maintaining ATP content and viability.