Connie Guo

This study shows that astrocytic Ca2+ signaling and CB1 receptors are required for tLTD at layer-5 pyramidal cell synapses in visual cortex.

The paper introduces optomapping, a fast 2-photon optogenetic method validated by paired recordings, to study excitatory microcircuit organization in mouse V1, revealing log-normal synaptic strength distributions, layer-specific connectivity, and novel short-term plasticity patterns.

This study describes the maturation of astrocytes in mouse visual cortex from postnatal day 3 to 30, showing changes in electrophysiology, morphology, and calcium signaling.