P. Jesper Sjöström

This study shows that astrocytic Ca2+ signaling and CB1 receptors are required for tLTD at layer-5 pyramidal cell synapses in visual cortex.

The paper investigates the role of presynaptic and postsynaptic NMDA receptors in synaptic plasticity and circuit structure in mouse visual cortex.

This study shows that tLTD in neocortical layer-5 pyramidal cell synapses depends on non-ionotropic preNMDAR signaling via JNK2/STX1a, challenging the traditional view of NMDARs as ionotropic coincidence detectors.

The paper introduces optomapping, a fast 2-photon optogenetic method validated by paired recordings, to study excitatory microcircuit organization in mouse V1, revealing log-normal synaptic strength distributions, layer-specific connectivity, and novel short-term plasticity patterns.

The paper maps Purkinje cell connectivity to cerebellar nuclear neurons, finding non-random, zone-specific patterns and suggesting that small Purkinje inputs can pause nuclear neuron output.

This study describes the maturation of astrocytes in mouse visual cortex from postnatal day 3 to 30, showing changes in electrophysiology, morphology, and calcium signaling.

The paper shows that local axonal translation regulates synapse-type-specific neurotransmission in the primary visual cortex through mTOR and cap-dependent mechanisms.

This paper investigates how pre- and postsynaptically expressed spike-timing-dependent plasticity (STDP) differentially affect neuronal learning in minimalist models.

The paper models spike-timing-dependent plasticity (STDP) expressed pre- or postsynaptically to show how different implementations affect learning outcomes in neuronal networks.

The paper introduces CosMIC, a new metric for evaluating spike inference accuracy in calcium imaging, showing it better discriminates precision and recall than existing metrics.

ABLE detects cell locations in two-photon calcium imaging data using a level set method, achieving 67.5% success on a manually labelled mouse in vivo dataset.

This review discusses the functional consequences of pre- and postsynaptic expression of homeostatic and Hebbian synaptic plasticity, highlighting predicted benefits like improved sensory perception and memory savings.