Hovy Ho‐Wai Wong

This study shows that tLTD in neocortical layer-5 pyramidal cell synapses depends on non-ionotropic preNMDAR signaling via JNK2/STX1a, challenging the traditional view of NMDARs as ionotropic coincidence detectors.

The paper introduces optomapping, a fast 2-photon optogenetic method validated by paired recordings, to study excitatory microcircuit organization in mouse V1, revealing log-normal synaptic strength distributions, layer-specific connectivity, and novel short-term plasticity patterns.

The paper shows that local axonal translation regulates synapse-type-specific neurotransmission in the primary visual cortex through mTOR and cap-dependent mechanisms.

The paper shows that ribosomal proteins are synthesized locally in axons and incorporated into ribosomes in a nucleolus-independent manner, regulated by a novel RNA motif.