William H. Thiel

ASSET: A Framework for Decoding Aptamer Specificity of an Enriched Library by Next-Generation Sequencing of Experimental Samples

ASSET quantifies aptamer specificity in enriched libraries using NGS, enabling accurate classification of true and false positives in SELEX processes.

AptamerRunner: An accessible aptamer structure prediction and clustering algorithm for visualization of selected aptamers

AptamerRunner clusters aptamers by sequence and structure to create visual networks for selecting high-quality candidates for experimental validation.

Identification of In Vivo Internalizing Cardiac-Specific RNA Aptamers

The paper identifies cardiac-specific RNA aptamers that selectively target and internalize into ventricular cardiomyocytes in vivo.

MIRO1 controls energy production and proliferation of vascular smooth muscle cells

This study shows MIRO1 regulates VSMC proliferation and neointima formation by controlling mitochondrial positioning, ATP production, and ETC function.