Michael Polymenis

The paper investigates how Cak1 levels and T169 phosphorylation of Cdc28 are regulated in yeast under different growth conditions, revealing a role for a uORF in controlling Cak1 synthesis and cell cycle dynamics.

This study shows that reducing folate intake in aged mice decreases biosynthetic processes but does not compromise healthspan, suggesting age-dependent benefits of folate restriction.

The paper identifies proteins that bind the FAS1 mRNA in yeast during the cell cycle and shows Tdh3p's role in regulating its translation and cell cycle progression.

This study investigates how one-carbon metabolic enzymes regulate cell cycle progression and metabolome in Saccharomyces cerevisiae, showing distinct effects of enzyme loss on cell size, growth, and metabolic profiles.

The paper identifies key phenotypic dimensions associated with cell cycle genes in yeast using computational methods to simplify phenotype categorization and gene function discovery.

The paper presents experiment-matched datasets of RNAs, proteins, metabolites, and lipids in budding yeast during the cell cycle, revealing coordinated control of lipid metabolism.

The paper identifies translational control of methionine and serine metabolic pathways as the mechanism underlying paralog-specific phenotypes in Rpl22 ribosomal protein mutants, linking these changes to cell division and replicative longevity.

The paper shows that gene expression and transcription-related processes influence cell size distribution in yeast by analyzing single-gene deletion strains.