Author

Seok Jae Lee

Seoul National UniversityORCID 0000-0003-1523-0012Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:simulation· 1

Frequent Co-Authors

Dong Hyun JoiD· 2 shared Sangsu BaeiD· 2 shared Seok‐Hoon LeeiD· 2 shared Dae Hee Lee· 1 shared Dongjoon ImiD· 1 shared Gue‐Ho HwangiD· 1 shared Hansol Koo· 1 shared Ho Byung Chae· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenetics

Dong Hyun JoORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintOct 23, 2024

Bystander base editing interferes with visual function restoration in Leber congenital amaurosis

Seok‐Hoon Lee, Jun Wu, Dongjoon Im…·Sangsu Bae

The paper shows that bystander base editing with ABE8e impairs visual function restoration in LCA model mice by causing structural and functional disruptions in RPE65.

3 citations

mouseCRISPR screen

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintNov 2, 2023

Adenine base editing corrects point mutation in mitochondrial single-stranded binding protein (SSBP1) to improve mitochondrial function

Ju Hyuen Cha, Seok‐Hoon Lee, Yejin Yun…·Sang‐Yeon Lee

This study corrects a SSBP1 mutation using adenine base editors, improving mitochondrial function but with trade-offs between editing efficacy and off-target risks.

DOI 10.1101/2023.11.02.23297943

humanwhole-genome sequencing

𝕏 PostBluesky