Author

Hansol Koo

Seoul National University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Ho Byung Chae· 2 shared Jae‐Jin SongiD· 2 shared Sang‐Yeon LeeiD· 2 shared Sangsu BaeiD· 2 shared Sung Ho JungiD· 2 shared Won Hoon ChoiiD· 2 shared Ai CheniD· 1 shared Biyun ZhuiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersGenetics

Ho Byung Chae

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2 papers

Recent·Most cited

PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation

Shao Wei Hu, Sohyang Jeong, Luoying Jiang, Hansol Koo, Zijing Wang, Won Hoon Choi, Biyun Zhu, Heeyoung Seok, Yi Zhou, Min Gu Kim, Dan Mu, Huixia Guo, Ziyi Zhou, Sung Ho Jung, Yingting Zhang, , Yilai Shu

This study uses base editing to correct a mutation causing hearing loss in a humanized mouse model, restoring hearing function and gene expression.

bioRxiv · Oct 29, 2024 · PreprintGenetics

Adenine base editing corrects point mutation in mitochondrial single-stranded binding protein (SSBP1) to improve mitochondrial function

Ju Hyuen Cha, Seok‐Hoon Lee, Yejin Yun, Won Hoon Choi, Hansol Koo, Sung Ho Jung, Ho Byung Chae, Dae Hee Lee, Seok Jae Lee, Dong Hyun Jo, Jeong Hun Kim, Jae‐Jin Song, Jong‐Hee Chae, Jun Ho Lee, Seung Ha Oh, , Sang‐Yeon Lee

This study corrects a SSBP1 mutation using adenine base editors, improving mitochondrial function but with trade-offs between editing efficacy and off-target risks.

medRxiv · Nov 2, 2023 · PreprintGenetic & Genomic Medicine