Dong Hyun Jo

Bystander base editing interferes with visual function restoration in Leber congenital amaurosis

The paper shows that bystander base editing with ABE8e impairs visual function restoration in LCA model mice by causing structural and functional disruptions in RPE65.

Adenine base editing corrects point mutation in mitochondrial single-stranded binding protein (SSBP1) to improve mitochondrial function

This study corrects a SSBP1 mutation using adenine base editors, improving mitochondrial function but with trade-offs between editing efficacy and off-target risks.

Therapeutic adenine base editing corrects nonsense mutation and improves visual function in a mouse model of Leber congenital amaurosis

This study uses adenine base editing to correct a nonsense mutation in a mouse model of LCA, improving visual function.

CRISPR-pass: Gene rescue of nonsense mutations using adenine base editors

CRISPR-pass uses adenine base editors to bypass nonsense mutations in patient-derived fibroblasts, showing potential for treating genetic disorders.