Robert J. Morell

This study shows that CASZ1 regulates outer hair cell maturation and is essential for hearing by controlling gene expression and F-actin density.

The paper develops an in vitro model of neonatal and adult stria vascularis and uses single-cell RNA sequencing to identify key genes and pathways involved in SV proliferation and maintenance.

This paper identifies a noncoding 10bp deletion in Hgf in mice that causes hearing loss by disrupting neural crest migration into the stria vascularis and reducing the endocochlear potential, mirroring human DFNB39 deafness.

The paper characterizes adult cochlear supporting cell transcriptional diversity using single-cell RNA-Seq in mice and validates findings in humans, identifying potential mechanisms for cochlear regeneration.

The paper uses single cell and single nucleus RNA-sequencing to identify cell populations and gene regulatory networks in adult mouse stria vascularis, linking known deafness genes to specific cell types.