Author

Jingjing Guo

University of ZurichORCID 0009-0002-3773-6399Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Adriano AguzziiD· 4 shared Assunta SenatoreiD· 2 shared Marco LosaiD· 2 shared Silvia SorceiD· 2 shared Simone HornemanniD· 2 shared Yingjun LiuiD· 2 shared Andra ChincisaniD· 1 shared Andrea ArmaniiD· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersNeuroscience

Adriano AguzziORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

NG2 glia protect against prion neurotoxicity by inhibiting prostaglandin E2 signaling

Yingjun Liu, Jingjing Guo, Maja Matoga, Marina Korotkova, Per‐Johan Jakobsson, Adriano Aguzzi

This study shows NG2 glia reduce prion-induced neurodegeneration by inhibiting PGE2 signaling, which promotes microglial activation and neurotoxicity.

bioRxiv · Apr 4, 2023 · PreprintNeuroscience

Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions

Yingjun Liu, Assunta Senatore, Silvia Sorce, Mario Nuvolone, Jingjing Guo, Zeynep Hulya Gumus, Adriano Aguzzi

This study develops an ex vivo mouse brain slice model that mimics brain aging and shows prions accelerate aging-related molecular changes.

Communications Biology · Jun 8, 2022Peer-reviewedNeuroscience

Robust and Versatile Arrayed Libraries for Human Genome-Wide CRISPR Activation, Deletion and Silencing

Jiang‐An Yin, Lukas D. Frick, Manuel C. Scheidmann, Tingting Liu, Chiara Trevisan, Ashutosh Dhingra, Anna Spinelli, Yancheng Wu, Longping Yao, Dalila Laura Vena, Britta Knapp, Elena De Cecco, Kathi Ging, Andrea Armani, Edward J. Oakeley, , Adriano Aguzzi

The paper constructs genome-wide CRISPR libraries for gene ablation, activation, and silencing with high efficacy and reports novel gene regulators and modifiers.

bioRxiv · May 25, 2022 · PreprintGenomics

Protective anti-prion antibodies in human immunoglobulin repertoires

Assunta Senatore, Karl Frontzek, Marc Emmenegger, Andra Chincisan, Marco Losa, Regina Reimann, Geraldine Horny, Jingjing Guo, Sylvie Fels, Silvia Sorce, Caihong Zhu, Nathalie George, Stefan Ewert, Thomas Pietzonka, Simone Hornemann, Adriano Aguzzi

The paper identifies protective anti-prion antibodies in human immunoglobulin repertoires and finds they are present in healthy individuals without associated pathologies.

EMBO Molecular Medicine · Aug 10, 2020Peer-reviewedNeuroscience