This study identifies alveolar macrophages as critical for ozone tolerance in mice, showing their role in reducing inflammation and injury through suppressed signaling pathways.

Toxicological Sciences · Jul 25, 2025Peer-reviewedPharmacology & Toxicology

Genetic Regulators of Sputum Mucin Concentration and Their Associations with COPD Phenotypes

Eric Van Buren, Giorgia Radicioni, Sarah Lester, Wanda K. O’Neal, Hong Dang, Silva Kasela, Suresh Garudadri, Jeffrey L. Curtis, MeiLan King Han, Jerry A. Krishnan, Emily S. Wan, Edwin K. Silverman, Annette T. Hastie, Victor E. Ortega, Tuuli Lappalainen, , Samir N. P. Kelada

This study identifies genetic variants associated with sputum mucin concentrations and links one variant to COPD phenotypes like chronic bronchitis and acute exacerbations.

PLoS Genetics · Jun 23, 2023Peer-reviewedGenetics

A novel gene-by-environment quantitative trait locus on mouse chromosome 15 underlies susceptibility to acute ozone-induced lung injury

Adelaide Tovar, Gregory J. Smith, Joseph M. Thomas, Kathryn M. McFadden, Samir N. P. Kelada

This study identifies a novel gene-by-environment QTL on mouse chromosome 15 associated with susceptibility to acute ozone-induced lung injury using the Collaborative Cross panel.

bioRxiv · May 20, 2021 · PreprintGenetics

Inferring the Allelic Series at QTL in Multiparental Populations

Wesley L. Crouse, Samir N. P. Kelada, William S. J. Valdar

This study introduces a Bayesian framework to infer allelic series in multiparental populations, distinguishing biallelic from multiallelic QTL and improving haplotype effect estimation.

Genetics · Oct 20, 2020Peer-reviewedGenetics

Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research

John Sebastian Sigmon, Matthew W Blanchard, Ralph Steven Baric, Timothy A. Bell, Jennifer Brennan, Gudrun A. Brockmann, A. Wesley Burks, J. Mauro Calabrese, Kathleen M. Caron, Richard E. Cheney, Dominic J. Ciavatta, Frank L. Conlon, David B. Darr, James E. Faber, Craig L. Franklin, , Fernando Pardo‐Manuel de Villena

The paper introduces MiniMUGA, a genotyping array for mouse genetic QC, showing it effectively discriminates strains, detects genetic constructs, and identifies sex chromosome abnormalities.

Genetics · Oct 17, 2020Peer-reviewedGenetics

Baseline and Innate Immune Response Characterization of a Zfp30 Knockout Mouse Strain

Lucas T. Laudermilk, Adelaide Tovar, Alison Homstad, Joseph M. Thomas, Kathryn M. McFadden, Miriya K. Tune, Dale O. Cowley, Jason R. Mock, Folami Ideraabdullah, Samir N. P. Kelada

This study investigates the role of Zfp30 in neutrophil recruitment and fertility using a knockout mouse model, finding no effect on neutrophilic inflammation but a reduction in live mutant offspring.

Mammalian Genome · Aug 1, 2020Peer-reviewedGenetics

Determinants of QTL mapping power in the realized Collaborative Cross

Gregory R. Keele, Wesley L. Crouse, Samir N. P. Kelada, William S. J. Valdar

The paper evaluates QTL mapping power in the Collaborative Cross using real genomes and simulations, providing guidelines for experimental design.

G3 Genes Genomes Genetics · Mar 26, 2019Peer-reviewedGenetics