Charles Y. Chiu

This study uses multiomic and spatial profiling of colorectal tissue and blood to show that Long COVID is linked to immune dysregulation and viral persistence, with stronger signals in tissue than blood.

This study uses rapid diagnostics and metatranscriptomics to analyze SARS-CoV-2 infection, revealing viral evolution, host responses, and drug interactions in NYC samples.

This study uses cell-free DNA methylation profiling in plasma to identify organ-specific injury and predict COVID-19 severity in hospitalized patients.

The paper validates a clinical metagenomic sequencing assay for detecting pathogens in cerebrospinal fluid, showing 73% sensitivity and 99% specificity compared to clinical tests.

This study improves the detection of m6A in bacterial DNA using nanopore sequencing with a binary classifier, highlighting the importance of read quality and comparing results to PacBio methylation calls.

This paper develops a metagenomic sequencing approach to diagnose lower respiratory tract infections by integrating pathogen detection, microbiome analysis, and host transcriptome data.

This study uses metagenomic sequencing to detect respiratory pathogens in hematopoietic transplant patients, finding it more sensitive than conventional methods and identifying new pathogens.

The paper uses ZIKV genomes to estimate the origin and spread of Zika virus in Brazil and the Americas, providing a timeframe for baseline microcephaly rates.

The paper identifies a persistent Zika virus lineage in Bahia, Brazil, using metagenomic sequencing and phylogenetic analysis.