BiophysicsJournal of the American Chemical SocietyPeer-reviewed
Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay
Alessia Santambrogio, Robert I. Horne, Michael A. Metrick…·Michele Vendruscolo
The paper develops an in vitro tau aggregation assay combined with machine learning to identify polymorph-specific tau inhibitors, validated in a Drosophila model.
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