Author

Michael A. Metrick

University of CambridgeORCID 0000-0002-9998-4630Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Organism:Drosophila· 1

Frequent Co-Authors

Michele VendruscoloiD· 3 shared Alessia SantambrogioiD· 2 shared Nicholas C. T. Gallagher· 2 shared Alessia SantambrogioiD· 1 shared Anna del Ser‐BadiaiD· 1 shared Anne HedegaardiD· 1 shared Bernardino Francesco GhettiiD· 1 shared Byron Caughey· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

Michele VendruscoloORCID

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3 papers

Recent·Most cited

Tracking tau and cellular responses in human iPSC-microglia from uptake to seedable secretion in extracellular vesicles

Maria Kreger Karabova, Anna del Ser‐Badia, Anne Hedegaard, Sam J. Washer, Zeynep Baykam, Darragh Patrick O'Brien, Iolanda Vendrell, Svenja Hester, Roman Fischer, Errin Johnson, Charlotte E. Melia, Teige R. S. Matthews-Palmer, Rishi Matadeen, Alessia Santambrogio, Michael A. Metrick, , Sally A. Cowley

This study shows human iPSC-derived microglia uptake and process tau fibrils, leading to secretion in extracellular vesicles that can seed tau aggregation in neurons.

Alzheimer s & Dementia · Apr 1, 2026Peer-reviewedCell Biology

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

Alessia Santambrogio, Sofia Lövestam, Michael A. Metrick, Thomas Löhr, Pu Xu, Nicholas C. T. Gallagher, Bernardino Francesco Ghetti, Byron Caughey, Sjors H. W. Scheres, Michele Vendruscolo

This study investigates tau filament assembly using mutant recombinant tau and brain homogenates, finding that specific mutations produce filaments resembling AD pathology.

FEBS Letters · Sep 30, 2025Peer-reviewedNeuroscience

Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay

Alessia Santambrogio, Robert I. Horne, Michael A. Metrick, Nicholas C. T. Gallagher, Z. Faidon Brotzakis, Dillon J. Rinauro, Ergina Vourkou, Katerina Papanikolopoulou, Efthimios M. C. Skoulakis, Sara Snogerup Linse, Byron W. Caughey, Michele Vendruscolo

The paper develops an in vitro tau aggregation assay combined with machine learning to identify polymorph-specific tau inhibitors, validated in a Drosophila model.

Journal of the American Chemical Society · Sep 18, 2025Peer-reviewedBiophysics