Akhil Jakatdar

This study uses single-nucleus DNA sequencing to analyze pancreatic cancer evolution, revealing patterns of mutation and copy number variation across clinical scenarios.

This paper introduces an algorithm to reconstruct longitudinal tumor phylogenies from single-cell sequencing data and demonstrates its ability to detect rare clones persisting through treatment.

The paper identifies clonal inflammatory microglia as a cause of neurodegeneration in LCH and ECD, showing their association with neuronal loss and suggesting CSF1R inhibitors as a therapeutic option.