Haochen Zhang

POLQ-driven repair scars shape the immunogenic landscape of homologous recombination-deficient pancreatic cancer

The paper identifies MDF, a repair scar linked to POLQ-driven error-prone repair, as a marker of immune-responsive HRD pancreatic cancer with increased neoantigens and favorable clinical outcomes.

Genomic evolution of pancreatic cancer at single-cell resolution

This study uses single-nucleus DNA sequencing to analyze pancreatic cancer evolution, revealing patterns of mutation and copy number variation across clinical scenarios.

Mechanism of neurodegeneration mediated by clonal inflammatory microglia

The paper identifies clonal inflammatory microglia as a cause of neurodegeneration in LCH and ECD, showing their association with neuronal loss and suggesting CSF1R inhibitors as a therapeutic option.

ConDoR: Tumor phylogeny inference with a copy-number constrained mutation loss model

ConDoR improves tumor phylogeny inference by integrating copy-number constraints with SNV data, outperforming existing methods on simulated data and producing more plausible phylogenies in real datasets.